Sex hormones, CSF and serum leptin in patients with idiopathic intracranial hypertension

Abstract Background Idiopathic intracranial hypertension (IIH) is typically seen in females of childbearing period; therefore, it possible that female sex hormones have a pathogenic role IIH. Obesity considered as strong risk factor for IIH, Leptin levels the serum and CSF were found to be positively correlated with anthropological measures obesity. The leptin pathogenesis idiopathic not fully understood. aim this work was assess leptin, estradiol, testosterone, Dehydroepiandrosterone sulfate (DHEAS) patients. Results This case control study which conducted on 38 IIH patients controls. had significantly higher Leptin, estradiol testosterone than controls ( P value < 0.001, 0.005 respectively), whereas there no statistically significant difference between DHEAS = 0.142). body mass index (BMI) ≥ 30 kg/m 2 BMI 0.009, respectively). Conclusions Patients express characteristic elevation levels. These are elevated high BMI.